Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

1. Introduction

While the structure and function of large blood vessels in the brain can easily be studied, the cerebral microvasculature remains difficult to access. Commonly used magnetic resonance imaging (MRI) brain tissue markers, including white matter hyperintensities (WMH), are assumed to be the macrostructural consequences of microvascular dysfunction, but do not provide a direct measure of cerebral microvascular function [

  • Wardlaw J.M.
  • Smith C.
  • Dichgans M.
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging.