Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges

Editorial

doi: 10.3389/fphar.2022.927812.

eCollection 2022.

Affiliations

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Editorial

Márcio Rodrigues et al.

Front Pharmacol.

2022.

doi: 10.3389/fphar.2022.927812.

eCollection 2022.

Affiliations

¹ CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
² CPIRN-UDI-IPG-Center for Potential and Innovation of Natural Resources, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda, Portugal.
³ Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India.

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No abstract available

Keywords:

brain targeting; central nervous system; intranasal drug delivery; nasal route; pharmacodynamics; pharmacokinetics.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Comment on

Editorial on the Research Topic Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges

References

1. Agarwal S. K., Kriel R. L., Brundage R. C., Ivaturi V. D., Cloyd J. C. (2013). A Pilot Study Assessing the Bioavailability and Pharmacokinetics of Diazepam after Intranasal and Intravenous Administration in Healthy Volunteers. Epilepsy Res. 105, 362–367. 10.1016/j.eplepsyres.2013.02.018
  
  –
  
  DOI
  
  –
  
  PubMed
1. Cartt S., Medeiros D., Gwozdz G. T. (2012). Patent US9763876B2. (United States: Applicant: Hale Biopharma Ventures LLC; ). Available at: https://patents.google.com/patent/US9763876B2/en .
1. Erdő F., Bors L. A., Farkas D., Bajza Á., Gizurarson S. (2018). Evaluation of Intranasal Delivery Route of Drug Administration for Brain Targeting. Brain Res. Bull. 143, 155–170. 10.1016/j.brainresbull.2018.10.009
  
  –
  
  DOI
  
  –
  
  PubMed
1. Fortuna A., Alves G., Serralheiro A., Sousa J., Falcão A. (2014). Intranasal Delivery of Systemic-Acting Drugs: Small-Molecules and Biomacromolecules. Eur. J. Pharm. Biopharm. 88, 8–27. 10.1016/j.ejpb.2014.03.004
  
  –
  
  DOI
  
  –
  
  PubMed
1. Hogan R. E., Tarquinio D., Sperling M. R., Klein P., Miller I., Segal E. B., et al. (2020). Pharmacokinetics and Safety of VALTOCO (NRL-1; Diazepam Nasal Spray) in Patients with Epilepsy during Seizure (Ictal/peri-ictal) and Nonseizure (Interictal) Conditions: A Phase 1, Open-Label Study. Epilepsia 61, 935–943. 10.1111/epi.16506
  
  –
  
  DOI
  
  –
  
  PMC
  
  –
  
  PubMed

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