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Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study



Bruno, Davide;

Jauregi Zinkunegi, Ainara;

Pomara, Nunzio;

Zetterberg, Henrik;

Blennow, Kaj;

Koscik, Rebecca Langhough;

Carlsson, Cynthia;

Mueller, Kimberly D; + view all

Bruno, Davide;

Jauregi Zinkunegi, Ainara;

Pomara, Nunzio;

Zetterberg, Henrik;

Blennow, Kaj;

Koscik, Rebecca Langhough;

Carlsson, Cynthia;

Bendlin, Barbara;

Okonkwo, Ozioma;

Hermann, Bruce P;

Johnson, Sterling C;

Mueller, Kimberly D;

– view fewer

(2022)

Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study.

Neuropsychology


10.1037/neu0000821.

(In press).

Abstract

OBJECTIVE: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are amyloid β 1-42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey’s Auditory Verbal Learning test (AVLT) were associated with these biomarkers. METHOD: Data from 235 participants (Mage = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer’s Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. RESULTS: We found moderate evidence that Rr was associated with both CSF p-tau (Bayesian factor [BFM] = 5.55) and t-tau (BFM = 7.28), above and beyond the control variables, while it did not correlate with CSF Aβ42 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFM = 3.57). CONCLUSIONS: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Type: Article

Title: Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1037/neu0000821
Publisher version: https://psycnet.apa.org/doi/10.1037/neu0000821
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Clinical, Neurosciences, Psychology, Neurosciences & Neurology, A/T/N biomarkers, Alzheimer’s disease, CSF tau, CSF A beta 42, recency ratio, MILD COGNITIVE IMPAIRMENT, WHITE-MATTER HYPERINTENSITY, ALZHEIMERS-DISEASE, AFRICAN-AMERICANS, DIAGNOSTIC GUIDELINES, WISCONSIN-REGISTRY, NATIONAL INSTITUTE, RECALL, RECOMMENDATIONS, PERFORMANCE
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10150818
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