Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration

Hong, Suk‐Min;

Yoon, Ji‐Young;

Cha, Jae‐Ryung;

Ahn, Junyong;

Mandakhbayar, Nandin;

Park, Jeong Hui;

Im, Junseop;

… Kim, Hae‐Won; + view all

Hong, Suk‐Min;

Yoon, Ji‐Young;

Cha, Jae‐Ryung;

Ahn, Junyong;

Mandakhbayar, Nandin;

Park, Jeong Hui;

Im, Junseop;

Jin, Gangshi;

Kim, Moon‐Young;

Knowles, Jonathan C;

Lee, Hae‐Hyoung;

Lee, Jung‐Hwan;

Kim, Hae‐Won;

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(2022)

Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration.

Bioengineering & Translational Medicine

10.1002/btm2.10332.

Text Knowles_Hyperelastic, shape memorable, and ultra cell adhesive degradable polycaprolactone polyurethane copolymer for tissue regeneration_VoR.pdf – Published Version Download (6MB)

Abstract

Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity,
shape-memory, and ultra-cell-adhesion properties are reported as clinically
applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxylated
or ethoxylated ones) were developed to improve mechanical properties by enhanced
reactivity in copolymer synthesis compared to the original isosorbide. Optimized
PCL-PU with propoxylated isosorbide exhibited notable mechanical performance
(50 MPa tensile strength and 1150% elongation with hyperelasticity under cyclic
load). The shape-memory effect was also revealed in different forms (film, thread, and
3D scaffold) with 40%–80% recovery in tension or compression mode after plastic
deformation. The ultra-cell-adhesive property was proven in various cell types which
were reasoned to involve the heat shock protein-mediated integrin (α5 and αV) activation,
as analyzed by RNA sequencing and inhibition tests. After the tissue regenerative
potential (muscle and bone) was confirmed by the myogenic and osteogenic responses in vitro, biodegradability, compatible in vivo tissue response, and healing
capacity were investigated with in vivo shape-memorable behavior. The currently
exploited PCL-PU, with its multifunctional (hyperelastic, shape-memorable, ultra-celladhesive,
and degradable) nature and biocompatibility, is considered a potential tissue-
regenerative biomaterial, especially for minimally invasive surgery that requires
small incisions to approach large defects with excellent regeneration capacity.

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