A Better Blood Test to Differentiate Epileptic From Psychogenic Nonepileptic Seizures?

Seizures are common in neurologic and general practice; some are genuine epileptic seizures (ES) and some are mimics, including psychogenic nonepileptic seizures (PNES). The precise classification can be challenging for clinicians, and our clinical impression is often wrong.1 Videos taken with cellphones can be helpful, but even then differentiation of ES from PNES can be difficult.2 Seizures are seldom captured in outpatient EEGs, and epilepsy monitoring units (EMUs) are scarce resources. Biomarkers have thus far been largely unreliable3 but still hold promise as an additional tool, especially when integrated with clinical features.

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