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AntiVPP 1.0: A portable tool for prediction of antiviral peptides.


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AntiVPP 1.0: A portable tool for prediction of antiviral peptides.

Comput Biol Med. 2019 Feb 19;107:127-130

Authors: Beltrán Lissabet JF, Belén LH, Farias JG

Abstract
Viruses are worldwide pathogens with a high impact on the human population. Despite the constant efforts to fight viral infections, there is a need to discover and design new drug candidates. Antiviral peptides are molecules with confirmed activity and constitute excellent alternatives for the treatment of viral infections. In the present study, we developed AntiVPP 1.0, an accurate bioinformatic tool that uses the Random Forest algorithm for antiviral peptide predictions. The model of AntiVPP 1.0 for antiviral peptide predictions uses several features of 1088 peptides for training and validation. During the validation of the model we achieved the TPR = 0.87, SPC = 0.97, ACC = 0.93 and MCC = 0.87 performance measures, which were indicative of a robust model. AntiVPP 1.0 is a fast, accurate and intuitive software focused on the assessment of antiviral peptides candidates. AntiVPP 1.0 is available at https://github.com/bio-coding/AntiVPP.

PMID: 30802694 [PubMed – as supplied by publisher]

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