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28 MESENTERIC TERTIARY LYMPHOID ORGANS INTEGRATED INTO THE INTESTINAL-DRAINING LYMPHATIC NETWORK ARE RESISTENT TO ANTI-TNF THERAPHY IN CROHN’S DISEASE MOUSE MODEL



Characterization of Crohn’s disease (CD) includes susceptible mucosal surfaces via abnormal intestinal permeability caused by either deregulated interactions between the bacterial flora and surface epithelial cells or an overwhelming host immune response. However, historical and recent studies demonstrate lymphatic vessel obstruction and lymphangitis as a critical component of CD. A hallmark of CD is lymphatic vessel swelling, poor drainage, with submucosal edema derived from the dysfunctional lymphatics.

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