FMT safe for patients with PSC, may lower ALP

Fecal microbiota transplantation in patients with primary sclerosing cholangitis was safe and may improve alkaline phosphatase levels, according to a study from The American Journal of Gastroenterology.
“It has been postulated that bacteria may stimulate an aberrant immune response resulting in the perpetuation of the biliary inflammation seen in PSC,” Jessica R. Allegretti, MD, MPH, from the Brigham and Women’s Hospital in Boston, Massachusetts, and colleagues wrote. “Restoration of the microbiome is a reasonable target for therapy in PSC because there is no treatment,

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