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Heart failure resulting from cancer treatment: still serious but an opportunity for prevention


Success in the diagnosis and treatment of many cancers has resulted in a growing population of people living either cured of cancer or with their cancer controlled as a chronic disease by long-term treatment. This success story in modern medicine has created a new problem with some survivors developing cardiovascular disease as a result of their cancer treatment.1 This is not a surprise given the biology of cancer and the strategies for treating cancer which frequently inhibit molecular pathways or cellular organelles critical for healthy cardiac function.

One of the most serious consequences of cardiotoxic cancer therapy is heart failure (HF) which can lead to significant morbidity and premature mortality.1–3 A growing number of cancer therapies may cause cardiac dysfunction, either via direct myocardial injury or by inhibition of essential molecular pathways for normal cardiac function in healthy hearts or pathways which…

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