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EHS

Polypill strategy at the heart of cardiovascular secondary prevention


Over recent decades, cardiovascular disease (CVD) has overtaken infectious diseases as the leading cause of death worldwide.1 This shift is partly due to the great advances in the treatment of infectious diseases and the success of associated public health campaigns. General public awareness of the importance of both preventing high-risk exposure and early therapy initiation and adherence has helped reduce the burden of communicable (infectious) diseases. This contrasts sharply with the story of non-communicable diseases such as CVD. The incidence of atherosclerosis (the single largest underlying cause of CVD) has increased exponentially due to the immense lifestyle changes witnessed first in developed countries but lately also in low-income and middle-income countries. This rapid worldwide change in lifestyle has resulted in dramatic increases of obesity, sedentarism, dyslipidaemia and hypertension, all of which are risk factors for atherosclerosis.

The control of modifiable cardiovascular risk factors, such as lipid levels and blood…

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