Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark.
J Eur Acad Dermatol Venereol. 2018 Sep 22;:
Authors: Hamann CR, Egeberg A, Wollenberg A, Gislason G, Skov L, Thyssen JP
BACKGROUND: The risk of prenatal, obstetric and birth complications in mothers with atopic dermatitis (AD), along with treatment use during pregnancy, is unknown.
OBJECTIVES: To examine the associations between prenatal, obstetric and birth complications in mothers with AD and describe the dermatologic care received during pregnancy.
METHODS: Mother-child pairs, in which the mother had a history of AD, were identified through the Danish Medical Birth Registry and matched 1:10 with non-AD pairs. Data on dermatologic treatment and prenatal, obstetric and birth complications were obtained through linkage via nationwide registers. Multiple logistic regression was performed.
RESULTS: We identified 10,668 births from 1997 through 2014 to women with AD. Women with a hospital/ ambulatory contact for AD during pregnancy had increased topical corticosteroid and ultra violet therapy use during pregnancy compared to prior. However, overall, women with AD received decreased dermatologic therapy during pregnancy compared to prior. In adjusted analysis, maternal AD was inversely associated with gestational diabetes (OR 0.79, 95%CI [0.68-0.92]), but positively associated with premature rupture of membranes (1.15 [1.05-1.27]) and staphylococcal neonatal septicemia (2.45 [1.33-4.49])-albeit the latter was rare. These associations did not meet statistical significance in sub-analysis where BMI data was available. No associations were found with preeclampsia, prematurity, or non-staphylococcal neonatal septicemia.
CONCLUSIONS: Women with AD during pregnancy mainly used topical corticosteroids and ultraviolet therapy to control their disease. While premature rupture of membranes and staphylococcal neonatal septicemia were over-represented in maternal AD, no associations were found with any other significant prenatal, obstetric or birth outcome. This article is protected by copyright. All rights reserved.
PMID: 30242910 [PubMed – as supplied by publisher]