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EHS

White matter repair and traumatic brain injury

Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S., contributing to about 30 percent of all injury deaths, according to the CDC. TBI causes damage to both white and gray matter in the brain, but most research to date has focused on protecting neuronal cell bodies in gray matter, and thus far, has yielded few promising clinical trials. But damage to white matter in TBI, which occurs in the corpus callosum, internal capsule and corticospinal tracts, is also significant. Executive function and memory are particularly dependent on intact white matter tracts, and, compared with focal lesions, white matter disruption is known to be a superior predictor of long-term clinical outcomes in TBI.

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