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Clostridium difficile Infection in Children

Clostridium difficile has long been recognized as the leading cause of antibiotic-associated infection in adults hospitalized.1 However, over the past few decades, Clostridium difficile infection (CDI) has been reported with increased frequency in the community as well as in the pediatric population. Furthermore, the emergence of a new hypervirulent strain, referred to as North American pulse type 1 strain (NAP1), has been associated with severe illness.
It is well known that CDI often occurs after antibiotic exposure, which disturbs the normal bowel microbiota and allows for overgrowth of C.

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