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How the immune system protects against Zika-induced neurological symptoms

A type of immune cell that produces a protein called CD4 plays an important role in protecting mice infected with the Zika virus against severe neurological disease, according to a study published September 6 in the open-access journal PLOS Pathogens by Amelia Kahler Pinto of Saint Louis University, and colleagues. Based on the findings, vaccines that induce strong responses from these immune cells, known as CD4+T cells, should be developed to prevent invasion of the Zika virus into the brain and spinal cord.

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