Extrapontine myelinolysis effects in intracranial langerhans cell histiocytosis: Case report

Langerhans cell histiocytosis (LCH) is an uncommon disease with an incidence of 0.2–2.0 cases per 100,000 children under 15 years of age [1]. The frequency in adults is not known. The hypothalamic-pituitary manifestations of LCH (often diabetes insipidus) are well known. Thus, complications with sodium level shifts may be present. Rapid changes of sodium concentrations are associated with osmotic demyelination syndromes including pontine and extrapontine demyelination. Here we present a case of a woman with intracranial LCH and subsequent diabetes insipidus who developed extrapontine myelinolysis after she missed doses of desmopressin and subsequent rapid correction of hypernatremia.

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