Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis.
Biomed Pharmacother. 2018 Aug 08;107:303-305
Authors: Madhu K, T P
BACKGROUND: During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage.
PURPOSE: In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes.
METHODS: Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA.
RESULTS: Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures.
CONCLUSION: This study suggests that Asiaticoside A may be effective against the progression of MS.
PMID: 30098548 [PubMed – as supplied by publisher]