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Editors’ note: Blood pressure from mid- to late life and risk of incident dementia

In “Blood pressure from mid- to late life and risk of incident dementia,” authors McGrath et al. found that elevated blood pressure (BP) during midlife, persistence of elevated BP into late life, and, among nonhypertensive patients, a steep decline in BP during mid- to late life were associated with an increased dementia risk. Commenting on the article, Drs. Lattanzi and Silvestrini suggest that the analysis of the pulsatile component of BP through pulse pressure, and the BP variability through average real variability, or residual SD, which takes account of temporal trends in BP, could provide a more nuanced perspective of the mechanisms linking vascular aging to neurodegeneration, and add insights toward potential future therapy.

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