TB vaccines ineffective against initial infection

In a recent phase 2 trial, an investigational tuberculosis vaccine, H4:IC31, and the bacille Calmette-Guérin, or BCG, vaccine both lacked efficacy against initial Mycobacterium tuberculosis infection.
However, BCG revaccination in adolescents who were first vaccinated during infancy was associated with a significant reduction in sustained M. tuberculosis infection, according to researchers.
“The efficacy of the primary BCG vaccine against disease is highly variable in the different populations; efficacy is thought to be greatest in persons without previous mycobacteria exposure and
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