Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy.
ACS Appl Mater Interfaces. 2018 Jul 19;:
Authors: Zeng Z, Zhao P, Liu L, Gao X, Mao HQ, Chen Y
Nanoparticle-based chemotherapeutics have gained widespread interest in medicine due to their tunable pharmacokinetics and pharmacodynamics. Various drug delivery vehicles have been developed including polymer, liposome nanoparticles, and some of them have already made clinical impacts. Despite these ad-vances, drug payload of these formulations is limited (typically < 10%). Here, we report a general and scalable approach to prepare lipid-coated solid drug nanoparticles by combining flash nanoprecipitation and extrusion technique, which enables optimization of individual steps separately and flexibility in selec-tion of nanoparticle surface functionalities. Using methotrexate as a model drug, the nanoparticles signifi-cantly outperformed free drug in tumor growth suppression.
PMID: 30024145 [PubMed – as supplied by publisher]