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Histrelin implantation in the pediatric population: A 10-year institutional experience.

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Histrelin implantation in the pediatric population: A 10-year institutional experience.

J Pediatr Surg. 2018 Sep 08;:

Authors: Swendiman RA, Vogiatzi MG, Alter CA, Nance ML

Abstract
PURPOSE: To perform the largest review of the safety and clinical management practices of histrelin implantation in children.
METHODS: A retrospective cohort study was performed including all patients (age ≤ 20) that underwent histrelin implant insertion, replacement, or removal by a single surgeon at a large pediatric tertiary care center (2008-2017). Data analyzed included patient demographics, procedure details, and complications.
RESULTS: A total of 377 patients, with a mean age of 9.3 ± 2.4 years, underwent 866 unique procedures (352 insertions, 329 replacements, and 185 removals) for a diagnosis of either central precocious puberty (343 patients, 821 cases) or gender identity disorder (34 patients, 45 cases). There were 271 (72%) female patients, 72 (19%) male patients, and 34 (9%) children in gender transition. Procedures were performed in three settings: 415 (47.9%) in the outpatient clinic, 401 (46.3%) in a sedation unit, and 50 (5.8%) in the operating room. The preferred setting shifted over time to more clinic-based procedures (9.4% vs. 62.9% in the first five vs. second five years, respectively). Complications were rare (1% of cases).
CONCLUSION: Histrelin implantation in the pediatric population is safe, with minimal morbidity. Implantation and removal in the clinic setting are appropriate for the majority of patients.
LEVEL OF EVIDENCE: Treatment study; Level IV.

PMID: 30262200 [PubMed – as supplied by publisher]

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