Are bone mineral density and fractures related to the incidence and progression of radiographic osteoarthritis of the knee, hip and hand in elderly men and women? the rotterdam study.
Arthritis Rheumatol. 2018 Sep 28;:
Authors: Bergink AP, Rivadeneira F, Bierma-Zeinstra SM, Carola Zillikens M, Arfan Ikram M, Uitterlinden AG, Van Meurs JB
OBJECTIVE: To examine the longitudinal relationship between bone mineral density (BMD) and the incidence and progression of knee, hip and hand osteoarthritis, and the relationship between prevalent vertebral and non-vertebral fractures and the incidence and progression of osteoarthritis in elderly men and women in the Rotterdam Study.
METHODS: Age- and sex-specific quartiles of baseline femoral neck BMD (FN-BMD) were constructed for a total number of 4,154 subjects. Radiographs were scored for incidence and progression of knee and hip osteoarthritis, and for incidence of hand osteoarthritis. Prevalent vertebral fractures were scored using the McCloskey/Kanis method, and prevalent non-vertebral fractures were reported by baseline interview.
RESULTS: Subjects in the highest quartile of FN-BMD had an increased risk of incident knee radiographic osteoarthritis (ROA) (OR 1.58; 95%CI: 1.14 to 2.18), and an increased risk of incident hip ROA (OR 1.57; 95%CI: 1.06 to 2.32) compared to the lowest quartile. No significant relationship was found between high FN-BMD and progression of knee or hip ROA, or the incidence of hand ROA. Prevalent vertebral and non-vertebral fractures were not related to the incidence or progression of knee or hip ROA. Vertebral fractures were however associated with incident hand ROA (OR 1.74; 95%CI: 1.02 to 2.98).
CONCLUSION: Results from the present study confirm earlier studies and thus provide strong evidence that high FN-BMD is a prognostic risk factor for the development of knee and hip ROA. Vertebral fractures were found to be a risk factor for incident hand ROA. This article is protected by copyright. All rights reserved.
PMID: 30264891 [PubMed – as supplied by publisher]